Suzetrigine As A Novel Non-opioid Analgesic: Reducing Postoperative Opioid Consumption In Autologous Breast Reconstruction
Abstract
PURPOSE: Postoperative opioid use remains high across surgical populations and contributes significantly to dependence, particularly among opioid-nave patients. Autologous breast reconstruction is associated with substantial postoperative pain, with 6-10% of patients developing opioid dependence following surgery. This highlights the need for effective non-opioid analgesics within multimodal pain regimens. Suzetrigine, a novel peripherally selective sodium channel blocker recently approved by the FDA for acute pain, acts by inhibiting voltage-gated sodium channels in peripheral sensory neurons, reducing pain signaling with minimal side effects that are common with opioid pain medications. The role of suzetrigine in autologous breast reconstruction has not been studied. Given the high pain burden in this population, this study aims to compare postoperative opioid requirements in patients receiving perioperative suzetrigine versus controls undergoing DIEP flap breast reconstruction. METHODS: Patients who underwent DIEP flap reconstruction were reviewed to identify two consecutive cohorts of 10 patients each: a control group without suzetrigine exposure (November-December 2023) and a study group with perioperative suzetrigine administration (July-October 2025). Patients treated in the intervening period were excluded due to intraoperative methadone use, which could confound postoperative opioid consumption. Data collected included patient demographics, operative details,…
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