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Discriminator-driven diffusion generative adversarial network for synthetic medical image generation

Dennis Chia Yin Lim

Swinburne figshare (Swinburne University of Technology), 2026

Abstract

This research project addresses the significant challenge of class imbalance in medical deep learning classification models, particularly when the abnormal class is underrepresented. Class imbalance can severely affect the classification performance of deep learning models, potentially leading to patient misdiagnosis and impeding clinician trust in AI adoption. In healthcare, class imbalance arises due to various factors, including the rarity of diseases or medical scenarios and data insufficiency for specific classes within large datasets. Existing solutions, such as traditional data augmentation and Generative Adversarial Networks (GANs) like DCGAN, as well as Conditional GANs like Pix2Pix and Stable Diffusion, have attempted to mitigate this issue, but with limitations.

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