Commentary on the fundamentals and development of artificial intelligence models in the life sciences and best research practices
Abstract
Machine learning has a long history in the life and natural sciences. In the age of artificial intelligence (AI), both the opportunities and challenges associated with predictive and generative modeling are increasing. To exert significant influence on experimental programs in interdisciplinary research, AI models and their predictions must be demystified as far as possible, and misconceptions regarding what highly complex models can and cannot do must be avoided. Furthermore, it is necessary to evaluate best practices for the use of AI in life science research including drug discovery. This contribution discusses the evolution of AI models in the life and natural sciences, as well as current developments and remaining challenges in this rapidly evolving field. It is dedicated to the memory of Terry R. Stouch, a valued colleague and dear friend whom I had the privilege of knowing for more than 30 years and who left us far too soon.
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