Editorial for “Correlation of Intravoxel Incoherent Motion and Diffusion Kurtosis MR Imaging Models With Reactive Stromal Grade in Prostate Cancer”
Abstract
Editorial for “Correlation of Intravoxel Incoherent Motion and Diffusion Kurtosis MR Imaging Models With Reactive Stromal Grade in Prostate Cancer” Tumor stromal microenvironment plays a critical role in determining the progression and eventual clinical outcome of many cancers, including prostate cancer. In prostate cancer, a vigorous host response to the epithelial tumor cells can lead to an altered stromal architecture, which is called the reactive stroma. The reactive stroma of prostate cancer is identified by an increased number of myofibroblasts, excessive capillary density, deposition of type-I collagen, and other extracellular matrix substrates. At present, a semiquantitative grading scale, known as the reactive stroma grade (RSG), has been established on percentage of reactive stroma in the tumor area that was evaluated based off of hematoxylin– eosin-stained sections: RSG 0—0%–5%; RSG 1—5%–15%; RSG 2—15%–50%; and RSG 3—>50%, respectively. Clinical studies have suggested that analyzing reactive stromal changes can provide valuable information and show independent prognostic potential. However, the diagnostic value of reactive stromal changes in prostate cancer is still under debate. The main limitation concern of RSG scale comes from the poor reproducibility due to bias of tissue biopsy and the heterogeneity of tumor microenvironment. On the other hand, nondestructive evaluation of tumor microenvironment provides a potential way to examine reactive stromal changes…
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