Editorial: Next-generation quantitative and synthetic biology: High-sensitivity, high-accuracy, and digital approaches
Abstract
The articles in this collection describe, review, and utilize recent developments of technologies, which enable us to tackle various practical challenges, from healthcare to bioproduction. The Research Topic thus covers a wide range of complexities, from molecules to cells to communities of cells, providing an outlook for the recent advances in studying, analyzing and engineering of biological systems across scales (Figure 1). Setting the stage all the way from the basic building-blocks of life processes, Kang et al. extensively reviewed how watching individual molecules shed light on the mechanisms that the cells employ to maintain their genomes. The surveyed literature of DNA-repair, employing fluorescence microscopy, exemplify how single-molecule methods unveil detailed molecular pathways, otherwise inaccessible via traditional bulk methods. For investigating biological systems with resolution beyond the diffraction limit (which was considered a fundamental, unsurmountable physical barrier for over a century), single-molecule imaging enabled superresolution microscopy, and was awarded with the Nobel Prize in 2014. Another superresolution modality, called the “structured illumination microscopy” (SIM), uses a known pattern of excitation beams to generate super-resolution images, and enables temporal resolution higher than that of its Nobel-winning counterpart. Akatay et al. used SIM to investigate the major endocytotic route in cells, i.e., formation of clathrin-coated…
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