Deciphering calcium signals in cells and tissues with tailored probes and models
Abstract
Calcium signals are among the most important chemical cues in cells. They underlie signal transduction pathways involved in the release of neurotransmitters and hormones, the contraction of muscle cells, as well as gene transcription and fertilization. The ‘Calcium and Cell Function’ FASEB Science Research Conference, which held its first meeting in 1987, is a main venue for presenting the latest insights and discoveries in the field of calcium signalling, proof of the dynamism and rapid evolution of this area of research with high translational potential, given that human disorders are linked to deregulated calcium homeostasis. The last edition of this Physiological Society-sponsored conference took place online in September 2021 in the wave of COVID-19 restrictions. Four review articles written by speakers who presented their latest breaking research on calcium signalling at the conference are published in this issue of the Journal of Physiology. These reviews nicely illustrate current strategies and challenges to develop novel approaches for studying calcium signalling and unravelling the role of calcium signatures in health and disease. The review by Valiente-Gabioud et al. (2022) tackles the challenge of deciphering the mechanisms regulating the free Ca2+ concentration in the extracellular fluid, a compartment that has been underexplored, in large part because of methodological constraints. Refined tools were developed some time ago to precisely track Ca2+ signals…
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