Response to Letter Regarding Article, “Clinically confirmed stroke with negative diffusion-weighted imaging magnetic resonance imaging: longitudinal study of clinical outcomes, stroke recurrence, and systematic review”
Abstract
We thank Reale et al1 for their interest in our study,2 and for describing their interesting case and suggestion that the absence of a diffusion-weighted imaging (DWI) lesion in a third of our patients with stroke was because of a shorter duration of ischemia.
Disappearing DWI lesions are well documented to be associated with short duration and lesser severity of ischemic insult in animal models.3 Similarly, in patients, milder strokes are less likely to produce a DWI lesion than severe strokes.4 Other factors influence DWI lesion visibility. The DWI lesion lasts longer in white than in …
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