Editorial for “Quantification of Regional Cerebral Blood Flow Using Diffusion Imaging With Phase‐Contrast”
Abstract
Editorial for “Quantification of Regional Cerebral Blood Flow Using Diffusion Imaging With Phase-Contrast” A well-known saying dictates that “what goes in, must come out,” thereby referring to one of the fundamental laws of classical physics stating that mass cannot be generated nor destroyed. The principle of conservation of mass can be used to quantify flow in a way which otherwise might be challenging or impossible. In the context of human physiology, the blood circulation can be considered as such a closed system. In the paper, the concept of a mass balance is adopted by the authors to quantitatively measure regional cerebral blood flow (rCBF) in the human brain. Their work builds upon more than three decades of research and development to either manipulate or measure the phase of the MR signal. This has enabled measuring physiological principles at different time scales and lengths, namely blood flow, perfusion, and diffusion of water molecules. Intravoxel incoherent motion (IVIM) imaging was introduced for jointly modeling diffusion and perfusion parameters using a bi-exponential function. This requires diffusion MRI measurements at a large range of diffusion weightings, or b-values. Follow-up work proposed to expand to a tri-exponential model, estimating perfusion-related diffusion, fast-free diffusion, and slow-restricted diffusion. By using a more accurate diffusion modeling, perfusion-related information could also be obtained with lower error, despite still as a…
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