Editorial for “Metastatic Diffusion Volume Based on Apparent Diffusion Coefficient as a Prognostic Factor in Castration‐Resistant Prostate Cancer”
Abstract
Editorial for “Metastatic Diffusion Volume Based on Apparent Diffusion Coefficient as a Prognostic Factor in Castration-Resistant Prostate Cancer” The management of advanced castration-resistant prostate cancer (CRPC) patients has evolved continuously in the past decades with the increasing availability of cutting-edge imaging technologies. Whole-body multiparameter MRI and positron emission tomography (PET) with specific tracers, such as prostate-specific membrane antigen (PSMA), fluciclovine, fluorodeoxyglucose (FDG), and so on, has demonstrated promising clinical value for treatment response monitoring of patients with metastatic CRPC. Because of its operational complexity and abundant information from large number of images, the growing adoption of whole-body MRI necessities a delicate combination of streamlined workflow, structured reporting mechanism, and identification of reliable biomarkers. The clinical interpretation of wholebody MRI is a comprehensive approach demanding a systematic evaluation of multiple contrast mechanisms, including diffusionweighted imaging (DWI), T1 and T2, which is detailed in the guideline for MET-RADS-P scoring process. Among all MRI contrasts, DWI is regarded to be most sensitive in detecting metastatic lesions. In addition to MRI, it is notable that, with the recent surge of molecular imaging-based theragnostic approach for treating late-stage prostate cancer, such as PSMA-labeled 177Lu/68Ga pair, PET/CT is rapidly gaining clinical…
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