Muscle Membrane Permeability Determined by 31P‐MRS and DT‐MRI as a Biomarker for the Progression of Becker Muscular Dystrophy
Abstract
We read with interest the article by Schrama et al. on a retrospective study measuring phosphodiesters (PDE) using phosphorus magnetic resonance spectroscopy (31P-MRS) and diffusion tensor magnetic resonance imaging (DT-MRI) to assess whether Mg 2+ and the random permeable barrier model (RPBM) could serve as biomarkers for disease activity in patients with Becker muscular dystrophy (BMD) [1]. In BMD patients, P-MRS showed reduced Mg 2+ levels and increased weighted pH, indicating increased membrane permeability, and was therefore proposed as a suitable biomarker for disease activity regardless of disease phase [1]. The study is noteworthy
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