Seeing What We Build—The Need for New Imaging Techniques in Myocardial Regeneration
Abstract
T he largest experience with stem cell therapy in theheart has been with bone marrow mononuclear cells (BMMCs). Several single-center studies have shown modest, and in some cases transient, increases in ejection fraction (EF) following BMMC injection in patients with reperfused myocardial infarction.1 While this experience clearly demon-strated the safety of BMMC injection, the imaging readouts used in these phase 1 to 2 studies did not provide a clear “stop or go ” signal on which to base further decisions. Several multicenter phase 3 studies of BMMC injection were thus conducted and have been negative, showing no significant changes in EF.2,3 A clear need, therefore, exists for more refined imaging tools to guide the development of regenerative therapies in the heart. Successful regeneration in the heart requires the injected cell to be delivered to the correct zone of the
Read the paper
Related studies
- Learning from First-Generation Qualitative Approaches in the IS Discipline: An Evolutionary View and Some Implications for Authors and Evaluators (PART 1/2)
- Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models
- Prosthesis: New Technological Opportunities and Innovative Biomedical Devices
- The history and future of neural modeling for cochlear implants
- Ryanodine receptors: waking up from refractoriness
- Novel Transgenic Rabbit Model Sheds Light on the Puzzling Role of Matrix Metalloproteinase-12 in Atherosclerosis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.