Neuro-Behcet's Syndrome with Miliary Tuberculosis Presenting with Features Mimicking Acute Tuberculous Meningitis
Abstract
Presenting with Features Mimicking Acute Tuberculous MeningitisA 14-year-old girl diagnosed with Behçet's disease 15 months previously presented at the emergency department with severe headache, fever, and vomiting.Chest radiographic and computed tomography findings were consistent with miliary tuberculosis, and pleocytosis and increased protein levels were found on examination of cerebrospinal fluid (CSF).Tuberculous meningitis associated with miliary pulmonary tuberculosis was suspected, and a four-drug regimen for tuberculosis plus intravenous dexamethasone was initiated.However, negative results of real-time polymerase chain reaction and CSF cultures led us to reconsider our initial diagnosis.On brain magnetic resonance imaging, the results supported neuro-Behçet's syndrome rather than tuberculous meningitis.However, it is unclear how miliary tuberculosis complicated neuro-Behçet's syndrome because the patient had no history of tuberculosis or contact with patients with tuberculosis, and had not used any immunosuppressive agents such as anti-tumor necrosis factor-alpha drugs.This is a very rare case of neuro-Behçet's syndrome associated with miliary tuberculosis.More commonly, cases of neuro-Behçet's syndrome presenting with features mimicking acute tuberculous meningitis have been reported.Neuro-Behçet's syndrome should be considered in patients with a history of Behçet's disease presenting with signs of meningeal irritation.
Read the paper
Related studies
- Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing
- Laboratory-based nationwide surveillance of antimicrobial resistance in Ghana
- Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains
- Incidence and factors associated with development of phlebitis: results of a pilot study cohort
- Efficacy of triple therapy with a proton pump inhibitor, levofloxacin, and amoxicillin as first-line treatment to eradicate Helicobacter pylori
- Ten-Day versus 14-Day Levofloxacin-Containing Triple Therapy for Second-Line Anti-Helicobacter pyloriEradication in Taiwan
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.