Bacteriological Profile and Antimicrobial Susceptibility Patterns of Uropathogens at a Tertiary Care Hospital in North India: A Retrospective Descriptive Study
Abstract
ABSTRACT:
Background: The main cause of urinary tract infections (UTIs) are Gram negative bacteria with Escherichia coli as the leading cause and other important pathogens such as Klebsiella pneumoniae, Pseudomonas aeuriginosa and Enterococcus faecalis . Over the years uropathogens have become resistant to commonly used antibiotics, including penicillin’s, cephalosporins and fluoroquinolones. Antimicrobial resistance (AMR) in UTIs is mainly caused by the misuse and overuse of antibiotics, recurrent infections, and healthcare-associated factors such as catheterization.
Objectives: The aim of this study was to describe the bacteriological profile and antimicrobial susceptibility patterns of uropathogens isolated from positive urine cultures at Chhatrapati Shivaji Subharti Hospital, Meerut, a tertiary care centre in North India and develop an institutional antibiogram to support empirical prescribing and antibiotic stewardship at this institution.
Materials & Methods: The study analysed 50 positive urine culture samples and their antimicrobial susceptibility records from July 2025 to December 2025. The isolates were identified, and antimicrobial susceptibility testing was performed using the disc diffusion method and automated Biomerieux Vitek 2 Compact machine. The collected data was analysed using descriptive statistics and Fisher’s exact test.
Results: Gram-negative bacteria accounted for 80.0% (40/50) of the culture-positive urine isolates. Escherichia coli was the most…
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