Prevalence, antibiotic susceptibility and associated risk factors for Extended Spectrum Beta-lactamase producing Enterobacteriaceae among patients suspected with urinary tract infection
Abstract
Abstract Background Nowadays, increasing extended-spectrum beta-lactamase-producing Enterobacteriaceae, which were a common cause of urinary tract infection, have become a global concern because they induce resistance to most of the antimicrobial classes and make treatment difficult. Objective This study aimed to determine the prevalence of extended spectrum beta-lactamase producing Enterobacteriaceae, antibiotic susceptibility and its associated factors among patients suspected with urinary tract infection at Wachemo University Nigist Eleni Mohammed memorial Comprehensive Specialized Hospital, Hosanna, Ethiopia. Methods A cross-sectional study design was conducted among 287 patients suspected of having urinary tract infection. Data on socio-demographic information, clinical data and possible risk factors were collected using a Kobo toolbox. Mid-stream and catheter urine samples were collected and processed to characterize the Enterobacteriaceae isolates. Urine specimens were mixed well and aseptically inoculated Mac-Conkey agar and CLED agar using a standard calibrated loop. Kirby Bauer disk diffusion technique was employed to determine antibiotic susceptibility. The presence of extended spectrum beta-lactamase confirmed by double disk synergy test and data was analyzed by statistical package for social science (SPSS) version 26. Results The proportion of Enterobacteriaceae UTI was 33% (95% CI: 27.7; 38.9%). 95 Enterobacteriaceae were identified with Escherichia coli…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 287 participants or records.
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