Antimicrobial susceptibility profile of multidrug-resistant uropathogens in community-acquired urinary tract infections in Spain: A multicenter GEIAP-SEIMC study
Abstract
Introduction: Urinary tract infections are one of the leading causes of antibiotic prescribing in Primary Care and they generate a high volume of urine cultures in Microbiology laboratories. The empirical management of these infections has been complicated by the increase in antimicrobial resistance.
Objective: To evaluate the antimicrobial susceptibility profiles of extended-spectrum β-lactamase (ESBL) and/or carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa isolated from urine samples of patients attending Primary Care in Spain during 2022.
Methods: A descriptive, retrospective, multicenter study including urine samples obtained in Primary Care and processed in 43 Spanish laboratories. Data were collected through a structured survey developed by the Primary Care Infection Study Group and distributed via the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).
Results: Escherichia coli and Klebsiella pneumoniae were the predominant uropathogens and they accounted for 8.4% and 10.3% respectively. The most frequent carbapenemase was OXA-48. Both ESBL-producing E. coli and K. pneumoniae showed high susceptibility to carbapenémicos and aminoglycosides, whereas ciprofloxacin and cotrimoxazole showed low activity. Susceptibility of ESBL-producing E. coli to fosfomycin and nitrofurantoin was 85.8% and 95.6%, respectively. Pseudomonas aeruginosa accounted for 1.7% of isolates, showing high susceptibility to antipseudomonal agents except for…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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