Suzetrigine: A Selective Inhibitor of the NaV1.8 Sodium Channel
Abstract
Opioid related adverse events are an important perioperative concern despite widespread adoption of combined analgesic approaches for pain management.Suzetrigine, a selective inhibitor of the NaV1.8 sodium channel for the treatment of moderate-to-severe acute pain, enables the use of a novel analgesic class in clinical practice.The goal of this scoping review is to analyze suzetrigine's pharmacokinetic, pharmacodynamic, and clinical evidence.Utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines, the online databases of PubMed, Embase, and ClinicalTrials.gov(January 2020 to February 2026) were systematically searched for various studies investigating NaV1.8-selective compounds in acute pain contexts.A total of five reviewers screened and extracted data with cross-examination.A total of 10 articles were identified to meet the specified inclusion criteria for this scoping review.These articles were recognized as peer-reviewed publications, clinical trial registry results, regulatory documents, conference abstracts, and preprints.Suzetrigine was found to be most effective when given orally twice daily, and its selectivity for NaV1.8 was up to 30,000 times greater than that of other sodium channel medications pursuing the same effect.Suzetrigine was associated with a decrease in gastrointestinal symptoms when compared to opioid counterparts, a decrease of up to 40%.Mechanistic studies reveal that NaV1.8…
Read the paper
Related studies
- Noninvasive and Point-of-Care Surface-Enhanced Raman Scattering (SERS)-Based Breathalyzer for Mass Screening of Coronavirus Disease 2019 (COVID-19) under 5 min
- De Novo Transcriptome Analysis and Detection of Antimicrobial Peptides of the American Cockroach Periplaneta americana (Linnaeus)
- Molecular Characterization and Expression Profiling of Tomato GRF Transcription Factor Family Genes in Response to Abiotic Stresses and Phytohormones
- Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner
- Update of the Pompe variant database for the prediction of clinical phenotypes: Novel disease‐associated variants, common sequence variants, and results from newborn screening
- Machine Learning-Based SERS Chemical Space for Two-Way Prediction of Structures and Spectra of Untrained Molecules
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.