Prevalence of quinolones resistance among patients with urinary tract infection at Menoufia
Abstract
ObjectiveThe aim of the study was to examine the prevalence of quinolone resistance and determine appropriate empiric antibiotics for patients with urinary tract infection (UTI).BackgroundUTI is the most common disease of the urinary tract and it is a major cause of morbidity in both hospitals and communities. Most infections arise from Escherichia coli. Quinolones are effective for treatment of UTIs. Therapy against infectious diseases with antimicrobial agents such as quinolones is very dynamic, with high probability for bacterial resistance.Patients and methodsThis study was carried out on 150 patients (80 patients suffering from UTI with positive bacterial growth; 55 patients with mixed growth; and 15 patients with Candida). All studied patients with positive bacterial growth were submitted to complete history taking, clinical examination, urine analysis, biochemical tests, bacterial count, urine culture, and antimicrobial sensitivity of all isolates to quinolone drugs (nalidixic acid, ciprofloxacin, levofloxacin, ofloxacin, and gatifloxacin).ResultsIn this study 80 (53%) patients had positive urine culture (54% male and 46% female). The most commonly isolated bacterium was E. coli (52.5%). Individuals over the age of 50 years were more frequently affected by UTI. The sensitivity of male and female patients to ciprofloxacin and levofloxacin showed a highly statistically significant difference (P < 0.001) for each, and sensitivity to ofloxacin, gatifloxacin, and nalidixic…
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