Factors associated with ciprofloxacin and levofloxacin resistance in gram-negative bacilli isolated from urinary tract infections
Abstract
Background and Objectives: Fluoroquinolones are one of the most frequently prescribed antimicrobial classes for the treatment of urinary tract infections (UTIs) of both hospital and community origin. This study aims to determine the frequency and the factors associated with resistance to ciprofloxacin and levofloxacin in gram-negative bacilli isolated from patients with UTIs treated in a hospital in southern Brazil. Methods: We performed a transversal and analytical study based on cases of urinary tract infection caused by gram-negative bacteria (GNB) in patients at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande/RS from August 2012 to July 2013. Independent variables such as the age and sex of patients, source of infection of the UTI and the characteristics of the bacterial strains were analyzed. Results: Of the 562 GNB analyzed, the total frequencies of ciprofloxacin and levofloxacin resistance were, respectively, 25.5% and 23.3% in strains of community origin and 62.6% and 59% in strains of hospital origin. The risk factors associated with ciprofloxacin and levofloxacin resistance were sex (male), infections acquired in the hospital, longer hospitalization times, and the presence of extended spectrum β-lactamases (ESBLs) in the bacterial strains. Conclusions: We observed a strong association between GNB resistance, the time spent in the hospital and the presence of ESBLs. To control antibiotic resistance and to reduce the cost of health care, a strong…
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.