Study the Effect of Ciprofloxacin and Diclofenac Combination Treating Urinary Tract Infection by Resistance E.coli 0157:H7 in Female Rabbits
Abstract
This study is designed to highlight some of the anti-bacterial effect for diclofenac aganist resist.E .coli0157: H7, as well as the ability of the diclofenac represented by anti-inflammatory and ciprofloxacin combat the exposure of urinary tract infection.The virulence components responsible for colonization and penetration also have a role in the pathogenicity of the resistant Escherichia coli 0157: H7 strain.Resistance Escherichia coli 0157 H7 for antibiotics decreases the cure rate.Repurposing Food and Drug Administration (FDA) approved medications against the contributing factors is a novel method to overcome this scarcity.The analgesic medication diclofenac was reported to have anti-virulence action against resistance Escherichia coli O157 :H7.This study aimed to demonstrate the antimicrobial effect of diclofenac, Ciprofloxacin, and a combination (diclofenac +ciprofloxacin) against clinical resistance E coli o157 H7 isolates by using Polymerase chain reaction (PCR).The presented study, all rabbits, forty-eighth adult female rabbit aged (6-8 weeks) and weighing between (1500 and 2000) gm., was randomly divided into six equal groups(8/each) groups injection 0.1 ml in 1 x 10 9 CFU Escherichia coli 0157: H7 by urinary catheterization route excepting in negative control and all groups resulted in a significant increase in urea creatinine, sodium, Potassium, chloride concentration in the blood after three days comparison with negative control and in all experimental period…
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