Correlation between increased consumption of fluoroquinolones in outpatients and resistance of Escherichia coli from urinary tract infections
Abstract
Sir, Increased use of fluoroquinolones may lead to increased fluoroquinolone resistance in Escherichia coli in the community.1 The correlation between fluoroquinolone consumption and resistance in urinary isolates of E. coli in Slovenia has been recently evaluated. In Slovenia, the outpatient consumption of fluoroquinolones increased from 0.59 defined daily doses (DDD)/1000 inhabitants/year in 1992 to 1.50 DDD/1000 inhabitants/ year in 1999, or from 0.27 to 7.64% of all outpatient antibiotic prescriptions. In children 15 years of age (16/174, 9.2%) than in children (1/93, 1.1%). In 1993, all E. coli isolated in children (n = 55) were susceptible to ciprofloxacin. In contrast, the resistance of E. coli to ciprofloxacin in adult patients increased from 3.6% (6/168) in 1996 to 9.2% in 1999.
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