Bacterial profile and antimicrobial resistance patterns among pediatrics patients with suspected bloodstream infections in Ethiopia: a systematic review and meta-analysis
Abstract
Background: Bloodstream infection (sepsis) represents a systemic inflammatory response to systemic infection by bacteria, fungi, and viruses that can lead to severe complications and death. The therapeutic management to reduce mortality and morbidity associated with sepsis is difficult due partly to (re)emergence of antimicrobial resistance. The choice of empirical antibiotics, therefore, partly depends on the pattern of local/national antibiotic resistance. This systematic review and meta-analysis aimed to determine the prevalence of bacteremia among pediatric patients with suspected bloodstream infections in Ethiopia, based on culture-confirmed bacterial isolates.
Methods: A comprehensive search of PubMed, Google Scholar, and grey literature was conducted for studies published between January 2010 and April 2024 on bacterial bloodstream infections and antimicrobial resistance. Laboratory-based observational studies reporting bacterial isolates and resistance patterns were included. Data from 23 eligible studies were extracted independently, organized in Excel, and analyzed using Stata version 14. Pooled prevalence estimates were calculated using a random-effects model. Heterogeneity was assessed via the I² statistic, publication bias through funnel plots and Egger's test, and sensitivity analysis evaluated the influence of individual studies.
Results: The pooled prevalence of bacterial bloodstream infections (BSIs) among pediatric patients in Ethiopia was 30.66% (95% CI:…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes
- Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
- Genomic Survey of E. coli From the Bladders of Women With and Without Lower Urinary Tract Symptoms
- Characterization of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017–18
- Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
- Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.