D-Mannose for prevention of recurrent urinary tract infection in adult women: An updated systematic review and meta-analysis of randomized controlled trials
Abstract
Purpose Approximately 50%–60% of adult women experience at least one episode of urinary tract infection (UTI) during their lifetime, with 20%–24% of them experiencing recurrence within a year. Several randomized controlled trials have explored the efficacy and safety of D-mannose for the prevention of UTI in adult women but reported conflicting results. Objective We performed a meta-analysis comparing D-mannose with placebo or no treatment for the prevention of UTI in adult women. Methods We systematically searched PubMed, Scopus, and Cochrane Central databases for studies comparing D-mannose with placebo or no treatment for the prevention of UTI in adult women. The outcomes of interest were recurrent UTIs during follow-up and adverse events. Heterogeneity was assessed using I2 statistics. Analysis followed the PRISMA guideline and was registered in the PROSPERO database. Results The systematic review identified 4 randomized controlled trials (RCTs) including 890 participants (D-mannose n = 447, 50.22%). Recurrent UTI (RR 0.44; 95% CI 0.18–1.11; p = .082; I2 = 90%) and adverse events (RR 2.19; 95% CI 0.68–7.05; p = .190; I2 = 79%) did not differ significantly between the groups at the end of follow-up. Conclusion Prophylaxis with D-mannose did not cause any difference in the risk of recurrent UTI during follow-up and adverse events in adult women. Fewer number of studies and heterogeneity in the results make it difficult to draw conclusions about the efficacy of D-mannose in…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 890 participants or records.
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