Antibiotic prophylaxis after extraction of urinary catheter prevents urinary tract infections: a systematic review and meta-analysis
Abstract
OBJECTIVE
To investigate the effect of antibiotic prophylaxis for consequent urinary tract infections (UTIs) after extraction of urinary catheter and further explore the association between the outcome and clinical characteristics of patients.
METHODS
We systematically searched PubMed, Cochrane Library, EMBASE, and ClinicalTrials.gov databases through March 2020. Studies were included if they inquired into antibiotic prophylaxis for UTIs after extraction of a temporary (≤14 days) urinary catheter. We used fixed-effect models to obtain pooled risk ratio (RR) estimates. Heterogeneity was evaluated with I2 value. Sensitivity analysis and subgroup analysis were also conducted to assess heterogeneity.
RESULTS
We finally included eight randomized controlled trials in our study. Only two studies showed that antibiotic prophylaxis can reduce the consequent UTIs after extraction of urinary catheters while six did not. Overall, antibiotic prophylaxis was associated with reduced UTIs (RR, 0.47, 95% CI 0.28 to 0.72, p<0.01, I2 = 31%). Subgroup analysis indicated that patients who are older than 60 (RR = 0.50, 95% CI: 0.33 to 0.76, p < 0.05, I2 = 29%) or received Trimethoprim/sulfamethoxazole (TMP/SMX) (RR = 0.21, 95% CI: 0.09 to 0.48, p < 0.01, I2 = 0%) or indwelling catheters for more than 5 days (RR = 0.34, 95% CI: 0.19 to 0.63, p < 0.01, I2 = 0%) could get more benefit from antibiotic prophylaxis after extraction of catheters.
CONCLUSIONS
Patients with catheters removed might get…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.