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Artificial intelligence for infection surveillance, risk stratification, and antimicrobial decision support in acute-care hospitals: a scoping review

Mustafa MH, Abu-Mahfouz MS, Saleh SA, Almagharbeh WT, Alturaiki SM, El Arab RA

Frontiers in artificial intelligence, 2026

Abstract

Background: Artificial intelligence (AI) has increasingly been proposed to strengthen infection surveillance, early risk stratification, antimicrobial decision support, and selected workflow functions in acute-care hospitals. However, the literature remains clinically heterogeneous, methodologically uneven, and conceptually fragmented, with technical performance often interprested too readily as evidence of clinical effectiveness. This scoping review aimed to map and synthesise the empirical literature on AI applications for infection surveillance and related hospital applications, while explicitly distinguishing technical performance from clinical utility, implementation relevance, and patient benefit.

Methods: We conducted a scoping review in accordance with PRISMA 2020 and PRISMA-ScR guidance. CINAHL, Cochrane Library, Embase, PubMed, Scopus, and Web of Science were searched for English-language empirical studies. Eligible studies examined AI applications relevant to infection surveillance, risk prediction, detection, antimicrobial decision support, or workflow-relevant hospital functions in acute-care settings. Findings were synthesised narratively by application domain and translational stage.

Results: Database searches yielded 884 records; 628 unique records underwent title and abstract screening, 180 full texts were assessed, and 39 studies were included. The literature was dominated by retrospective model-development and validation studies; no randomised trials or…

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