Janus nanomotors for topical treatment of radiation-induced dermatitis
Abstract
Topical treatment remains the standard for radiation-induced dermatitis, which affects approximately 95% of radiotherapy patients. However, the robust skin barrier significantly restricts transdermal drug permeability, compromising therapeutic efficacy. Here we show a NIR-Ⅱ light and endogenous H2O2 dual-propelled Janus nanomotor (Au-hSiO2-Pt-TA), which enhances skin permeability by a factor of 12.8 compared with passive nanoparticles. By leveraging the synergistic advantages of self-thermophoresis and self-electrophoresis, these motors enable non-invasive, deep penetration through directional movement. Intriguingly, we find that NIR-II-induced hyperthermia (~ 45 °C) triggers neuro-immune regulation via the CGRP-RAMP1 axis, which suppresses inflammatory cell recruitment and migration while polarizing macrophages toward a pro-repair phenotype, thereby alleviating radiation-induced systemic inflammatory responses. Additionally, tannic acid loaded on the nanomotors functions as an efficient ROS scavenger, further mitigating radiation-induced oxidative stress. Overall, the movable nanomotors offer a potent strategy for RD and demonstrate high efficacy through combined neuro-immunoregulation and ROS scavenging. The barrier function of the skin limits dermally delivered attempts to treat radiation induced dermatitis. Here, the authors report on the use of NIR-II light and endogenous H2O2 dual-propelled nanomotors for immune regulation and ROS scavenging to reduce radiation-induced…
Read the paper
Related studies
- Noninvasive and Point-of-Care Surface-Enhanced Raman Scattering (SERS)-Based Breathalyzer for Mass Screening of Coronavirus Disease 2019 (COVID-19) under 5 min
- De Novo Transcriptome Analysis and Detection of Antimicrobial Peptides of the American Cockroach Periplaneta americana (Linnaeus)
- Molecular Characterization and Expression Profiling of Tomato GRF Transcription Factor Family Genes in Response to Abiotic Stresses and Phytohormones
- Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner
- Update of the Pompe variant database for the prediction of clinical phenotypes: Novel disease‐associated variants, common sequence variants, and results from newborn screening
- Machine Learning-Based SERS Chemical Space for Two-Way Prediction of Structures and Spectra of Untrained Molecules
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.