P57 Prevalence of antimicrobial resistance in acute community-acquired urinary tract infections in Sub-Saharan Africa: a systematic review
Abstract
Abstract Background Urinary tract infections (UTIs) are one of the most common bacterial infections globally and a leading cause for outpatient visits. In Sub-Saharan Africa, widespread over the counter dispensing of antibiotics and limited healthcare resources contribute to high levels of antimicrobial resistance (AMR) in the community. However, data on AMR in community-acquired UTIs remain scarce. This systematic review addresses this knowledge gap by synthesizing the available evidence on AMR in this patient population. Objectives We aimed to determine the resistance rates of the most common pathogens causing community-acquired UTIs in Sub-Saharan Africa to the antibiotics most frequently prescribed for their treatment. Additionally, we sought to evaluate whether resistance patterns varied geographically or temporally within the region. Methods A systematic search was conducted for peer-reviewed literature published between 1 January 2000 and 1 November 2024 using Medline, Embase and Global Health databases. The search strategy captured studies evaluating AMR in community-acquired UTIs within the target region. Exclusion criteria included: studies with less than 10 bacterial isolates and those involving patients with comorbidities that predispose them to complicated infections. Studies were screened independently by two reviewers at the title, abstract and full text stages before extracting data onto a standardized spreadsheet. Quality assessment was done using an adapted…
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