Patterns of Antimicrobial Resistance in Urinary Tract Infection Pathogens: Analysis in a Provincial Hospital in Zimbabwe
Abstract
Introduction. Urinary tract infections (UTIs) are among the most common infections globally. Rising multidrug-resistant uropathogens in Zimbabwe underscore the need to review their susceptibility profiles. This study examines antimicrobial susceptibility trends of uropathogens in patients from Victoria Chitepo Provincial Hospital. Methods: This retrospective study included 385 randomly selected UTI-positive patients from 2023. Midstream, clean-catch urine samples were processed using standard microbiological techniques, and statistical analysis was conducted. Results: More females (56.4%) than males (43.6%) had UTIs, with age groups 0–9 and 20–29 years most affected (16.6% each). The predominant uropathogens were E. coli (27.2%), K. pneumoniae (18.4%), Staphylococcus spp. (17.4%), and Enterobacter spp. (12.2%). E. coli was most susceptible to ceftriaxone (93%) and most resistant to doxycycline; K. pneumoniae was most susceptible to chloramphenicol (70.4%). Conclusion: E. coli was the most common uropathogen. Most uropathogens showed susceptibility to ceftriaxone, gentamicin, and chloramphenicol. However, Staphylococcus spp. displayed resistance to norfloxacin, ciprofloxacin, nalidixic acid, and doxycycline. The high resistance rates highlight the need for antimicrobial stewardship and confirmatory testing before prescribing.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.