Antimicrobial activity of nitrofurans (nitrofurantoin, furazidine and furazidine potassium) against uropatogenic Escherichia Coli isolated from patients with lower urinary tract infections
Abstract
Currently, the problem of antibiotic resistance is of great relevance to society not only for medical, but also for social and economic reasons. Infections caused by multidrug-resistant pathogens have a longer course, more often require hospitalization, and increase the risk of mortality. The antimicrobial resistance is most relevant for hospitals in the case of the development of nosocomial infections. However, in recent years in Russia and Europe, resistant microorganisms have become more often found in patients with community-acquired urinary tract infections. In this review, we present data from two recent large Russian studies on antibiotic resistance of community-acquired strains of uropathogens and a microbiological study carried out in Switzerland to study the antimicrobial activity of furazidin, soluble furazidin, nitrofurantoin and ciprofloxacin. For the first time, an evaluation of the antimicrobial activity of soluble furazidin allowed to explain the high clinical efficiency of furazidin potassium, documented in trials and real clinical practice. This study, in line with Russian data, indicates the high activity of nitrofurans against Escherichia coli, the main causative agent of UTI.
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