Antimicrobial Resistance Profiles of Bacterial Pathogens Associated with Acute Diarrheal Disease: A Three-Year Retrospective Study in a Romanian Tertiary-Care Hospital
Abstract
Background: Despite its typically self-limiting course, acute diarrheal disease continues to be clinically relevant from an antimicrobial resistance surveillance perspective. In-depth analyses at a national level remain limited, with available Romanian studies from the last decade focusing on individual pathogens, often relying on a restricted isolate collection. In this context, we aimed to evaluate antimicrobial resistance profiles and distribution of Salmonella spp., Campylobacter spp., Escherichia coli, Yersinia spp. and Shigella spp.
Methods: Data was obtained from records from the Microbiology Laboratory of a tertiary-care hospital serving the south region of Romania, over a 3-year period.
Results: Campylobacter spp. had high resistance rates to ciprofloxacin (81.65% for C. jejuni; 85.15% for C. coli) and tetracycline (44.65% for C. jejuni; 56.07% for C. coli). Erythromycin resistance remained low and stable over the study period, with no statistically significant temporal variation; however, C. coli isolates demonstrated significantly higher erythromycin (p = 0.001) and tetracycline (p = 0.008) resistance rates compared to C. jejuni. Overall Salmonella spp. resistance rate to ciprofloxacin was 46.00%, with higher resistance observed in serogroups C (63.64%) and D (52.53%) (p p E. coli isolates reacting with pathotype-associated O antisera revealed high resistance levels to ampicillin (41.57%), amoxicillin-clavulanic acid (AMC) (38.73%) and…
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