Bloodstream Infections and Antibiotic Susceptibility Among Patients With Positive Blood Cultures at a Tertiary Care Hospital in Sri Lanka
Abstract
Introduction: Bloodstream infections (BSIs) are a major cause of sepsis and in-hospital mortality. Context-specific data on antimicrobial resistance are essential for guiding empiric therapy.
Methods: A retrospective study was performed among 100 patients with clinically significant positive blood cultures admitted to the medical wards of Teaching Hospital Batticaloa, Sri Lanka, from January 1 to June 30, 2022. Demographic, clinical, microbiological, and outcome data were extracted from patient records. Associations between selected variables and clinical outcome were analyzed using the Statistical Package for Social Sciences version 26 (IBM Corp., Armonk, NY).
Results: The mean age was 53.6 years (SD = 16.31), and 82 (82%) had comorbidities, mainly diabetes mellitus. Coliforms caused 54 (54%) BSIs, and Staphylococcus aureus caused 19 (19%), of which 10/19 (52.6%) were methicillin-resistant Staphylococcus aureus. Urosepsis was the commonest focus of coliform bacteremia, while central line infection was the leading focus in S. aureus bacteremia. Among isolates tested, Coliforms remained susceptible to amikacin (34/35; 97.1%) and carbapenems (30/31; 96.8%), with low susceptibility to the third- and fourth-generation cephalosporins. S. aureus isolates showed good susceptibility to trimethoprim-sulfamethoxazole and clindamycin, and all isolates tested against penicillin were resistant. Among the patients with known outcomes, in-hospital mortality was 30/90 (33%). Age under 40…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 100 participants or records.
Read the paper
Related studies
- Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes
- Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
- Genomic Survey of E. coli From the Bladders of Women With and Without Lower Urinary Tract Symptoms
- Characterization of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017–18
- Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
- Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.