P47 Addressing the increasing burden of infection and AMR in older people: a propensity-score-matched case-control analysis of urinary tract infection management and outcomes in and outside care homes in England
Abstract
Abstract Background Rising drug-resistant urinary tract infection (UTI) affects older population disproportionally worldwide, particularly amongst those living in care homes. UTI in care homes were not characterized, and the quality of infection management was not assessed. In this study, we aimed to examine incidence, service and health outcomes of community-acquired UTIs in older adults, comparing those inside and outside care homes. Methods We linked and analysed primary, secondary, social care records and pathology data of 2.5 million London population between 2018 and 2023. We matched older adults with UTI in and outside care homes using propensity scores. We performed time-series analysis of UTI incidence rate. We assessed UTI-related outcomes using generalized estimating equations (GEE), adjusted for demographic and other risk factors. Results A total of 91 501 UTI cases were analysed; 6648 were from care homes. The incidence rate was 19.1 per 1000 person-months in care homes with an increasing upward trend (increasing by 3.7 per month, P=0.014), compared to 5.4 outside while declining (decreasing by 1.3 per month, P=0.014). During the COVID-19 pandemic, the UTI incidence increased by further 180.8 episodes per 1000 person- months (P=0.004) in care homes, while declining outside by further 25.9 (P=0.027). Diagnostic tests, particularly urine culture, were less used in care homes, and the laboratory turnaround was slower. Adherence to diagnostic guidance was lower in…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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