Retrospective analysis of antimicrobial resistance among Escherichia coli causing community-acquired urinary tract infections in the United States from 2010-2022
Abstract
OBJECTIVES
A retrospective analysis of Escherichia coli isolates collected from community-acquired urinary tract infections (UTIs) in the United States for the years 2010-2022 was performed. The data originated from accessing the SENTRY Antimicrobial Surveillance Program, which is a global monitoring program that has been ongoing since 1997 with a purpose of tracking and reporting susceptibility of clinical isolates collected from various infection sources.
METHODS
Isolates meeting the Centers for Disease Control and Prevention definition for community-acquired UTI were tested for antimicrobial susceptibility against 17 antimicrobial agents using broth microdilution methodology specified by the Clinical & Laboratory Standards Institute (CLSI) guidelines. Isolates were interpreted as susceptible, intermediate, or resistant as appropriate using CLSI and European Committee on Antimicrobial Susceptibility Testing breakpoints and characterized for extended-spectrum β-lactamase and multidrug-resistant phenotypes.
RESULTS
The percentage of isolates susceptible to the oral agents amoxicillin-clavulanate, trimethoprim-sulfamethoxazole, and fluoroquinolones was 70%-85% throughout the study period, which crosses the acceptable threshold of 80% for empiric use of trimethoprim-sulfamethoxazole per the 2010 Infectious Disease Society of America guidelines. Higher susceptibility (>90%) was observed for all agents administered via intravenous or intramuscular route. Variation in…
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