2828. Incidence of Treatment Failure When Treated with Empiric Oral Antibiotics Among US Female Outpatients with Uncomplicated Urinary Tract Infection
Abstract
Abstract Background More than half of all women experience a urinary tract infection (UTI) in their lifetime, with most diagnoses classified as uncomplicated (uUTI). Management of uUTIs is impacted by treatment failure (TF), which may be driven by antibiotic (ABX) resistance and is associated with an increased risk of suboptimal outcomes. This study aimed to investigate the occurrence of TF to empirically prescribed oral ABX treatment in female outpatients with uUTI and characterize those failing versus not failing treatment. Methods Retrospective data from Optum’s de-identified Clinformatics Data Mart Database dataset were used to assess female outpatients aged ≥12 years between January 2017 and September 2022 (Figure 1). Eligibility criteria included ≥1 uUTI diagnosis (i.e., no evidence of complicated UTI) with ≥1 empiric prescription of nitrofurantoin (NTF), trimethoprim-sulfamethoxazole (SXT), fluoroquinolones (FQ), fosfomycin, or beta-lactams (BL) within ±5 days of diagnosis (date of initial ABX prescription defined the index date), and ≥12 months of electronic health record activity before and after the index date. TF was defined as any of the occurring ≤28 days after the index date: second oral ABX prescription, administration of intravenous ABX, or a primary diagnosis of acute UTI in the emergency room or inpatient setting. Data source: Optums de-identified Clinformatics Data Mart Database from January 1, 2017 to September 30, 2022. *Oral ABX treatments included NTF,…
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