Prevalence of Extended Spectrum β-lactamase and AmpC β-lactamase among Escherichia coli and Klebsiella pneumoniae in Urinary tract infections
Abstract
There are an estimated 150 million cases of urinary tract infection (UTIs) reported each year, putting it among the most prevalent infectious diseases. The study aimed to estimate the prevalence of AmpC β-lactamase and Extended spectrum β-lactamase (ESBL) production amidst E. coli and Klebsiella pneumonia strains from UTI cases. A total of 406 non-repetitive urine samples (203 isolates of E. coli and K. pneumoniae each) were analyzed. The study revealed significant prevalence of MDR strains, with 157 isolates (77%) of E. coli and 171 isolates (84%) of Klebsiella showing resistance to multiple antibiotics. 195 isolates (96%) of E. coli and 179 isolates (88%) of K. pneumoniae showed highest levels of resistance to Ciprofloxacin and Cefoxitin, respectively. Production of ESBL was found in 128 isolates (63%) of E. coli and 75 isolates (37%) of K. pneumoniae by Disc diffusion method, while Putative AmpC was seen in 103 isolates (51%) of E. coli and 120 isolates (59%) of K. pneumoniae by Combination disc test. These findings highlight the immediate need for robust antibiotic stewardship practices and effective strategies for infection control to manage UTIs, particularly against MDR strains, adopting targeted antibiotic treatment based on patient-specific factors and local resistance pattern.
Read the paper
Related studies
- Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes
- Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
- Genomic Survey of E. coli From the Bladders of Women With and Without Lower Urinary Tract Symptoms
- Characterization of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017–18
- Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
- Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.