Multidrug resistance bacteria causing community acquired urinary tract infections among adult outpatients attending lower-level health facilities in Mwanza, Tanzania
Abstract
Background: Urinary tract infections (UTIs) remain a common clinical condition requiring antibiotic prescription among adult outpatients in low- and middle-income countries (LMICs). Data regarding the prevalence, patterns of bacteria and their antibacterial susceptibility profile for community acquired UTI are limited. Methods: A hospital-based cross-sectional study was conducted from May to August 2024 at Igoma and Buzuruga Health Centres in Mwanza. Symptomatic adults patients, without recent hospitalization (within past 30 days) or urinary catheterization were enrolled. Clinical and demographic data were collected followed by standard mid-stream urine culture and disc diffusion susceptibility testing. Descriptive data analysis was performed using STATA version 15. Results: A total of 1,005 adult patients with the median age of 32 [IQR: 23-49] years were recruited, of whom 727 (72.3%) were female. The majority (64.3%) reported a previous history of UTI (within six months), and the median symptom duration before presentation was 8 [5-15] days. Microbiological confirmation of UTI was found in 221 patients (22.0%, 95% CI 19.5%-24.7%). The most frequently isolated uropathogens were Escherichia coli (32.9%) and Staphylococcus aureus (24.7%). Escherichia coli isolates were [≥]50% resistant to ciprofloxacin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, tetracycline, and ampicillin. About 20.3% of E. coli isolates showed positive extended-spectrum beta-lactamase…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 1,005 participants or records.
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