Antimicrobial resistance pattern for gram-negative uropathogens isolated from hospitalised patients and outpatients in Cartagena, 2005-2008
Abstract
OBJECTIVE: Determining the microbial aetiology spectrum and antibiotic resistance pattern of uropathogens causing urinary tract infections in hospitalised patients and outpatients.
METHODS: A descriptive study was carried out between February 2005 and November 2008 at the San Buenaventura University's Clinical Laboratory in Cartagena. Antibiotic sensitivity was determined by the Kirby Bauer method.
RESULTS: Out of the total specimens (1,384) analysed over the four-year study period, 455 of the urine samples (32.9 %) were culture positive, most (81.4 %) having come from females. The bacterium isolated most frequently was Escherichia coli (60.1 %) followed by Klebsiella pneumoniae (6.9 %), Pseudomonas aeruginosa (6.6 %), Proteus mirabilis (5.4 %) and Acinetobacter baumannii (1.4 %). The Gram-negative isolates displayed a high level of resistance to ampicillin (range 84.3100 %), amoxicillin/clavulanic acid (range 66.580 %) and ciprofloxacin (range 4057.9 %).
CONCLUSION: Gram-negative bacteria were responsible for urinary tract infections in the patients involved in this study. The most commonly isolated bacteria were E. coli. Empirical administration of a third-generation cephalosporin for initial treatment of urinary tract infections in this population appears prudent from the perspective of antimicrobial susceptibility.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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