Evaluasi dan Analisis Hubungan Profil Kepekaan Antibiotik pada Profil Pasien Infeksi Saluran Kemih di RSUD Dr. Pirngadi di Kota Medan
Abstract
Urinary tract infection (UTI) is one of the most common bacterial infections worldwide, with increasing concern regarding antimicrobial resistance caused by inappropriate antibiotic utilization. This study aimed to evaluate antimicrobial susceptibility patterns and identify factors associated with antibiotic resistance among patients with UTI at Dr. Pirngadi Hospital Medan. An analytical cross-sectional study was conducted involving 57 patients who met the inclusion criteria. Clinical characteristics, urine culture results, bacterial identification, antibiotic administration patterns, and antimicrobial susceptibility profiles were analyzed using the Chi-Square test. The results demonstrated that Escherichia coli was the predominant uropathogen causing UTI (43.9%), followed by Staphylococcus spp. (26.3%), Klebsiella spp. (19.3%), and Sphingomonas paucimobilis (10.5%). Ceftriaxone was the most frequently administered antibiotic (28.1%), followed by ciprofloxacin (22.8%) and meropenem (15.8%). Overall, 66.7% of isolates remained susceptible to tested antibiotics, whereas 33.3% exhibited resistance patterns. Statistical analysis revealed a significant association between urine culture results and antimicrobial susceptibility profiles (p<0.001), as well as between antibiotic administration patterns and bacterial susceptibility (p<0.001). These findings highlight the critical role of microbiological identification and antimicrobial susceptibility testing in guiding rational…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 57 participants or records.
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