Clinical Features and Outcomes of Myroides Species Infections
Abstract
Abstract Background Myroides species, Gram-negative bacilli from the Flavobacteriaceae family, are typically considered low-virulence pathogens but have previously been described as extensively drug-resistant. This study investigates the clinical features and outcomes of Myroides infections. Methods We conducted a retrospective cohort study of patients hospitalized at Cleveland Clinic with Myroides infection. Infections were defined as a positive Myroides culture from a sterile site that were treated with an antibiotic to which the isolate was susceptible. Controls were hospitalized patients with a positive culture for Myroides, who did not meet the definition for infection. Survival for infected patients and uninfected controls was compared using Cox proportional hazards regression. Results Between January 2015 and September 2023, 52 positive Myroides species cultures were identified, with 21 deemed infections. A higher proportion of Myroides-infected patients than controls had diabetes mellitus. The most common infections were skin/soft-tissue infections (42.8%), osteomyelitis (33.3%), and urinary tract infections (19%); and 28.5% were bacteremic infections. All isolates were resistant to aminoglycosides, but the majority were susceptible to trimethoprim-sulfamethoxazole (81%), ciprofloxacin (57%), and meropenem (68%). The main antimicrobial treatments provided were meropenem, ciprofloxacin, and trimethoprim-sulfamethoxazole. A significant difference in survival was not…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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