Disseminated multidrug-resistant Salmonella enterica serovar Dublin infection associated with plasmid-borne CMY-2 gene in a patient with travel to a farm in Mexico
Abstract
Disseminated Salmonella enterica infections represent a severe form of non-typhoidal salmonellosis increasingly complicated by antimicrobial resistance. We describe a case of disseminated non-typhoidal Salmonella in a man presenting with septic shock concerning for a thoracoabdominal endovascular graft infection with involvement of the urinary and respiratory tracts and thoracic skeleton. Hybrid whole-genome sequencing identified Salmonella enterica serovar Dublin and two significant plasmids, an IncC multidrug resistance plasmid harboring blaCMY-2, blaTEM-206, tet(A), and sul2 and an IncFII(S)/IncX1 virulence plasmid containing a spvA-D/spvR operon associated with systemic infection. This case highlights a potential food-borne or zoonotic acquisition of invasive, plasmid-mediated AmpC-producing Salmonella Dublin.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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