Genitourinary Tuberculosis Presenting As Testicular Malignancy and Resulting in Tuberculous Autonephrectomy
Abstract
Genitourinary tuberculosis is a common form of extrapulmonary tuberculosis and may mimic malignancy and chronic bacterial infection, leading to delayed diagnosis and irreversible organ damage. We report a case of genitourinary tuberculosis in a 41-year-old man presenting with chronic epididymal inflammation, a testicular mass, and progressive hydronephrotic destruction of the left kidney. Imaging findings initially raised suspicion for testicular malignancy. Histopathological examination following orchifuniculectomy demonstrated extensive necrotising granulomatous inflammation without evidence of malignancy, while acid-fast bacilli were not identified. Molecular testing of urine samples detected Mycobacterium tuberculosis complex deoxyribonucleic acid (MTBC DNA), and one of several mycobacterial urine cultures subsequently yielded positive growth for Mycobacterium tuberculosis. Imaging demonstrated destructive changes of the left kidney and mild bilateral apical pulmonary lesions compatible with tuberculosis, while sputum and bronchial aspirate microscopy, culture, and Xpert Mycobacterium tuberculosis and Rifampicin (MTB/RIF) testing (Cepheid, Sunnyvale, USA) remained negative. Anti-tuberculosis treatment was initiated. Because of complete functional loss and extensive parenchymal destruction, laparoscopic nephrectomy was required. Histopathological examination of the nephrectomy specimen confirmed necrotising granulomatous inflammation consistent with renal tuberculosis.…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.