Not Your Usual Culprit: Relapsing Salmonella enterica Serovar Infantis Urinary Tract Infection
Abstract
Urinary tract infection due to Salmonella enterica serovar Infantis (S. Infantis) is exceptionally rare and typically linked to host vulnerabilities. We report a case of a woman in her 60s with metastatic renal cancer, diabetes, chronic kidney disease, and prior splenectomy who developed three episodes of UTI within a year. Repeated urine cultures grew S. Infantis, and whole-genome sequencing confirmed relapse from intestinal colonization. After sequential short antibiotic courses, sustained resolution followed a seven-day regimen combined with reinforced pet-related hygiene measures. This case highlights the importance of considering unusual uropathogens, using genomic tools to confirm persistence, and addressing potential zoonotic reservoirs.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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