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Uncomplicated Urinary Tract Infections: From an Invisible Impact to a Visible Change in Complex Care

Cantón R, Lim AN, Cortés V, Díaz-Regañón J

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026

Abstract

Uncomplicated urinary tract infections can cause significant physical and emotional burden for patients, with high rates of recurrence. The challenges of treating uncomplicated urinary tract infections are exacerbated by rising antimicrobial resistance in key uropathogens, primarily Escherichia coli, on a global scale. Clinicians should consider drug, pathogen, and host-related factors when selecting the most appropriate therapy.

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