The Effect of Canephron N in Preventing Urinary Tract Infection: A Systematic Review and Meta-Analysis
Abstract
ABSTRACT Aim Urinary tract infections (UTIs) are among the most common bacterial infections, particularly in women, with significant implications for quality of life and healthcare costs. This systematic review and meta‐analysis aimed to evaluate the efficacy and safety of Canephron N in preventing UTIs, comparing its effects to antibiotics and assessing its potential as an antibiotic‐sparing alternative. Methods We conducted a comprehensive literature search across multiple databases (Embase, PubMed, Cochrane, Web of Science, and ClinicalTrials.gov ) up to July 2025, following PRISMA guidelines. Risk of bias was assessed using Cochrane RoB 2 for RCTs and ROBINS‐I for non‐randomized studies. Meta‐analyses were performed using random‐effects models, with outcomes including bacteriuria presence, Acute Cystitis Symptom Scores (ACSS), and adverse events. Heterogeneity was quantified via the I 2 statistic. Results From 246 initially identified records, 12 studies (eight RCTs, three observational, one retrospective; n = 3821 patients) were included. Canephron N demonstrated non‐inferiority to antibiotics in reducing UTI recurrence (6‐month rates: 8.9% vs. 17.8%) and symptom severity (ACSS reduction: −1.9 to −2.3 points). Pooled analyses revealed significant difference in bacteriuria clearance (RR: 1.34, 95% CI: 1.20–1.48, p < 0.0001) and no significant adverse events (RR: 0.90, 95% CI: 0.69–1.18, p = 0.43), though gastrointestinal events were less frequent with Canephron (4.8% vs.…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 3,821 participants or records.
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