Effectiveness of postoperative cephalosporins in reducing urinary tract infections and other parameters following transurethral resection of the prostate: a systematic review and meta-analysis
Abstract
BackgroundTransurethral resection of the prostate (TURP) is the standard surgical procedure for alleviating bladder obstruction caused by benign prostatic hyperplasia (BPH). Although effective, TURP is associated with the risk of urinary tract infection (UTI), which may be reduced by postoperative cephalosporin use.ObjectiveThis study aimed to determine the efficacy of cephalosporins in reducing the risk and complications of UTI following TURP.MethodsThe MEDLINE, Embase, and Cochrane Central databases were searched for randomized controlled trials (RCTs) that compared cephalosporin antibiotics with no intervention in patients undergoing TURP. The outcomes of interest for this systematic review and meta-analysis were UTI, length of stay, adverse effects, and postoperative days. Evaluations were reported as risk ratios (RR) and mean differences (MD) with 95% confidence intervals, using weighted random-effects models.ResultsThe Data Analysis included 668 participants from seven RCTs. Postoperative cephalosporin treatment after TURP significantly reduced the incidence of UTI compared with that in the control group (OR 0.37, 95% CI [0.22, 0.61], P<0.001, I²=30%). However, no significant difference was observed between postoperative cephalosporin use and the length of stay (MD -0.36, 95%CI [-1.13, 0.40], P=0.35, I²=81%), postoperative days (MD 0.20, 95% CI [-0.12, 0.53], P=0.22, I²=74%), and rate of adverse events (OR 0.94, 95% CI [0.58, 1.51], P=0.79;…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 668 participants or records.
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