Analysis of Pathogen Spectrum and Drug Resistance in Urinary Tract Infection of Senile Patients
Abstract
Objective: To guide the clinical drug use by studying the spectrum of pathogens isolated from urinary tract infection in senile patients and the drug resistance to antibiotics.Methods:All the pathogens isolated from urine in senile patients from 15 hospitals of Hubei province during 2002.Bacterial susceptibility test was carried out by using Kirby-Bauer method.A WHONET-5 computer software was used to analyze the results.Results:Five hundred and thirty-four strains including 409 strains ( 76.6%) of Gram negative bacilli and 125 strains ( 23.4%) of gram positive cocci were collected. E.coli, Klebsiella and Staphylococcus were the main microorganisms. 16.7% of E.coli and 22.7% of Klebsiella were suspected to produce extended-spectrum β-lactamase. The effective agents against Gram negative organisms were imipenem,amikacin,ceftazidine.While the drug resistance rate of G- bacilli to ciprofloxacin,gentamycin and piperacillin were above 50%. The drug resistance rate of gram positive cocci to SMZCO and erythromycin were above 40%,but the vancomycin resistant strain had not been found.Conclusions:The drug resistance of bacteria in senile patients , urinary tract infections is increasing. Gram negative bacilli were the main pathogen, and were susceptible to imipenen,amikacin and cefatazidine.Vancomycin is the first choice to treat infection with Gram positive cocci.
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