Comparison of Efficacy of Nitrofurontoin and Ciprofloxacin in Urinary Tract Infections Due to Escherichia Coli
Abstract
Background: Urinary tract infections (UTIs) impose a global health challenge contributing to a significant number of morbidity and mortality. Also, increasing trend Antimicrobial resistance (AMR) is a thing of great concern. This study is aimed at evidence based empirical guidelines in cases of UTI due to infection by Escherichia coli. Since more than 80% isolates were E.coli in this region we aimed at this particular species. Objective: To compare the efficacy of Nitrofurontoin and Ciprofloxacin in cases of urinary tract infections due to Escherichia coli. Place And Duration: This is a retrospective observational analysis and the study was conducted in Srinivas Institute of Medical Sciences and Research Centre, Mukka, Suratkal, Mangalore, in the Department of Microbiology from May 2025 to December 2025. Materials and Methods: A total of 1200 patients with Urinary tract infections were selected for the study. Clean catch mid-stream samples were collected from adult patients with aseptic precautions. Bacterial flora were isolated by standard microbiological methods and antimicrobial susceptibility testing was done by Kirby Bauer?s disc diffusion method. A Chi-square test was performed to compare the sensitivity of Escherichia coli isolates to Nitrofurantoin and Ciprofloxacin. Sensitivity to Nitrofurantoin (89.1%) was significantly higher than Ciprofloxacin (71.7%). Results: A total of 1200 samples were analysed of which 870 cases were sterile. 330 samples were culture…
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