Genome-confirmed Pluralibacter gergoviae urinary tract infection in a companion animal in Peru
Abstract
BACKGROUND
Urinary tract infections (UTIs) are common in dogs and are most frequently caused by Enterobacterales such as Escherichia coli and Klebsiella pneumoniae. The involvement of uncommon Enterobacterales with the capacity to acquire antimicrobial resistance is increasingly recognized within a One Health framework.
CASE PRESENTATION
A 3-year-old intact female mixed-breed dog presented with hematuria, lethargy and anorexia. Urinalysis and bacterial culture confirmed a urinary tract infection. The isolate was initially misidentified as Klebsiella pneumoniae by routine biochemical methods, but whole genome sequencing enabled its definitive identification as Pluralibacter gergoviae, a species previously reported mainly as an environmental and industrial contaminant and as an opportunistic human pathogen.
RESULTS
Antimicrobial susceptibility testing showed susceptibility to all tested agents except penicillin. Whole genome sequencing revealed no acquired antimicrobial resistance genes, and phylogenomic analysis clustered the canine isolate with human and environmental P. gergoviae strains from different geographic regions.
CONCLUSIONS
This genome-confirmed canine infection expands the known host range of P. gergoviae and highlights the role of molecular diagnostics in detecting atypical uropathogens. The phylogenomic relatedness to human and environmental strains underscores the importance of One Health-oriented genomic surveillance of opportunistic Enterobacterales across…
Read the paper
Related studies
- Horizontal gene transfer in the human gastrointestinal tract: potential spread of antibiotic resistance genes
- Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
- Genomic Survey of E. coli From the Bladders of Women With and Without Lower Urinary Tract Symptoms
- Characterization of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017–18
- Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
- Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.