O07 The economic and clinical burden of antibiotic-resistant community-acquired Escherichia coli urinary tract infections
Abstract
Abstract Background Antibiotic resistance increases healthcare usage and the economic burden of infection. Objectives To quantify the clinical burden and economic costs associated with antibiotic resistance in community-acquired Escherichia coli urinary tract infections. Methods We identified E. coli urinary tract infections using linked microbiology data and GP clinical records from the Whole System Integrated Care (WSIC) dataset between September 2018 and July 2023 in Northwest London (NWL). These were defined as positive E. coli urine cultures with an associated UTI prescription, a lower UTI diagnosis, or symptoms (±3 days for community cultures; -3 to 0 days for hospital cultures). UTI episodes were excluded for cases with incomplete follow-up, hospital-associated infections (admission within 30 days prior) and incomplete information (no resistance testing). Clinical outcomes were tracked over the following 60 days and costed using relevant literature, including community-based GP encounters (PSRU - Unit Costs of Health and Social Care), antibiotic prescriptions (NHS drug tariff), urinary diagnostics (literature) and secondary care activities: UTI-related hospital admissions, A&E attendances and outpatient activity. All secondary care costs were calculated using the NHS tariff from Health-Related Group Costings. Costs were uprated to 2023. Univariate analysis of health outcomes was conducted using the chi-squared test. A generalized linear model was employed to assess…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 8,508 participants or records.
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