Antibiotic Resistance Profiling of Klebsiella Pneumoniae Isolated from Urinary Tract Infection Patients
Abstract
Klebsiella pneumoniae is a gram negative, rod shaped, encapsulated pathogenic bacterium that led to hospital acquired and community acquired urinary tract infections. Nowadays it is a major threat to humans due to antibiotic resistance. This problem and treatment could have been overcome by proper use of the existing and new antimicrobial agents. The present study is undertaken to determine the antibiotic resistance profiling of K. pneumoniae isolated from patients having urinary tract infections (UTIs). K. pneumoniae isolates were identified by using standard methods such as culture methods, microscopy, and biochemical tests. Antimicrobial susceptibility testing was performed by the Kirby–Bauer disk diffusion method. A total of 215 urine samples were examined from May-2024 to October-2024. Out of the total samples, 118 samples (54.88%) have significant growth. In the positive isolates, 49 samples (41.52%) were male and 69 sample (58.47%) were female. Out of 118 K. pneumoniae isolates, 39 (33.05%) were extended-spectrum β-lactamases (ESBL) producer which have high resistivity power as compared to Non-ESBL Producer. Production of ESBLs is a major resistance-mechanism that makes difficult the antimicrobial to treat the infections caused by K. pneumoniae and is a serious threat to the currently available antibiotics. In the present study, K. pneumoniae was found more sensitive to Imipenem (92.4%), while more resistance to Ceftazidime (70.3%). The K. pneumoniae also showed…
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