Clinically Meaningful Improvements in Long COVID Symptoms Following Ketogenic Metabolic Therapy Combined with Lifestyle Interventions-A Clinical Case Report and Review of the Literature
Abstract
Approximately 400 million individuals globally are estimated to suffer from Long COVID, an infection-associated chronic condition that occurs after SARS-CoV-2 infection. Despite the high burden, there are no evidence-based or FDA-approved interventions to treat the condition. Given its complexity, a multicomponent approach grounded in a whole-person health model is likely required. This case report highlights clinically meaningful improvements in multiple Long COVID symptoms following a remotely-delivered, ketogenic metabolic therapy combined with group health coaching. Nutritional interventions were paired with exercises to stabilize circadian rhythms and introduce mindfulness-based practices. A review of the literature provides evidence in support of ketogenic metabolic therapy and lifestyle interventions as strategies to target proposed underlying mechanisms of Long COVID and foster stress resilience, thus reducing symptoms and improving quality of life. Findings support future research to optimize and evaluate multimodal nutritional and lifestyle interventions for Long COVID.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 400 participants or records.
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